US Highways Route - US51
| Route | From | To | Miles | States passed through | Replaced by | Notes |
| US 51 | Hurley, WI | La Place, LA (New Orleans, LA) | 1286 (1359) | WI IL KY TN MS LA | IL-2 IL-251 IL-351 US 61 I-10 | Since 1926; S trunc 1951 |
| US 151 | Manitowoc, WI | Homestead, IA + | 337 | WI (IL) IA | IL-35 US 20 | Since 1926; S exten Cedar Rapids, IA 1934; in IL during a bridge replacement near Dubuque, IA from 1971-1982; Curr S exten 1996 |
| US 53 | International Falls, MN * | La Crosse, WI | 403 (407) | MN WI | WI-70 US 63 WI-253 WI-124 | Since 1926; N exten 1934 |
| (US 55) | (Minneapolis, MN) | (Davenport, IA) | (368) | (MN) (IA) | MN-55 MN-3 MN-50 US 52 US 67 | Exist 1926-1934; Exten S 1932; N trunc Prosper, MN 1934 |
| US 57 | Moore, TX | Eagle Pass, TX * | 103 | TX | Nill | Added 1970; Runs E-W; Replaced TX-57; cntd to Mexico City, MX via MX-57 |
| (US 59) [I] | (Lake City, MN) | (Ostrander, MN -) | (76) | (MN) | US 63 | Exist 1934; Probably planned to exten S to Oskaloosa, IA |
| US 59 [II] | (Pembina, ND *) Lancaster, MN * | Laredo, TX * | 1911 (1959) | (ND) MN IA MO KS OK AR TX | US 81 I-29 US 75 CR-6 MN-32 US 169 KS-146 OK-2 US 60/69 US 412 AR-59 US 67 TX-8 US 96 Alt US 90 US 181 TX-359 | Since 1934; Orig S end Port Arthur, TX; S trunc Tenaha, TX 1939; S exten 1939; Cntd to Winnipeg, MB, Canada via MB-59 |
| US 159 | (Craig, MO) New Point, MO + | Nortonville, KS | 85 (86) | MO NE KS | MO-111 | Since 1934; Orig N begin Horton, KS; Exten N 1937 |
| US 259 | Zoe, OK + | Nacogdoches, TX + | 250 | OK TX | Nill | Since 1963 |
U.S. Highways
| US 1 | US 11 | US 21 | US 31 | US 41 |
| US 51 | US 61 | US 71 | US 81 | US 91 |
| US 2[I] | US 10 [I] | US 20 [I] | US 30 | US 40 |
| US 50 | US 60 | US 70 | US 80 | US 90 |