US Highways Route - US 50
| Route | From | To | Miles | States passed through | Replaced by | Notes |
| US 50 | Ocean City, MD | West Sacramento, CA (San Francisco, CA) | 3011 (3231) | MD DC VA WV MD WV OH IN IL MO KS CO UT NV CA | MD-450 Alt US 1 US 29 US 1 VA-236 WV-16 US 50S IL-250 IL-161 MO-100 MO-350 US 56 CO-120 CO-115 UT-128 US 6 US 89 UT-73 UT-68 UT-201 I-80 UT-138 I-80 Alt US 93 US 93 NV-722 CA-99 I-5 I-205 I-580 I-80 | Since 1926; /N//S//N//S/ E + W sects cntcd 1928; W exten Hayward, CA 1931; San Francisco, CA 1935; E exten 1948; W trunc Oakland, CA 1971; Manteca, CA 1972; Curr 1973; The Lonliest Road in America |
| US 150 | Mount Vernon, KY | Moline, IL (Rock Island, IL) | 571 (590) | KY IN IL | US 6 IL-92 | Since 1926; E exten 1934; W exten 1934; W trunc 1977 |
| (US 250) [I] | (Baldwin City, KS) | (Garden City, KS) | (391) | (KS) | US 50S | 1925 plan; On some early maps |
| US 250 [II] | Richmond, VA | Sandusky, OH | 514 | VA WV OH | OH-259 OH-302 | Since 1930; Orig rte Grafton, WV - Norwalk, OH; E extnd 1934; W exten 1933 |
| US 350 | La Junta, CO | Trinidad, CO | 80 (84) | CO | Nill | Since 1926 |
| (US 450) | (Walsenburg, CO) | (Crescent Jct., UT) | (465) | (CO) (UT) | US 160 CO-145 CO-184 US 160 US 666 US 163 [II] US 191 | Exist 1926-1939; E trunc Lockerby, UT 1934 |
| US 550 | Montrose, CO | Bernalillo, NM | 303 | CO NM | NM-541 US 64 | Since 1926; S exten Shiprock, NM 1934; S trunc Farmington, NM 1989; Aztec, NM 1999; S exten 1999 |
| (US 650) | (Buena Vista, CO) | (Salida, CO) | (27) | (CO) | US 285 CO-291 | Exist 1926-1936 |
| US 52 | Charleston, SC | Portal, ND * | 2072 (2121) | SC NC VA WV KY WV KY WV OH IN IL IA MN ND | WV-152 US 50 MN-55 MN-3 MN-952A MN-122 US 169 US 10 MN-23 MN-27 MN-231 US 10 ND-3 | Since 1926; E exten Bluefield, WV 1931; Curr 1934; US 52 in MN 1934; W exten 1935 |
| (US 152) | (Indianapolis, IN) | (Whiting, IN) | (176) | (IN) | US 52 US 231 US 41 IN-152 US 20 | Exist 1934-1938 |
| US 54 | (Chicago, IL) Griggsville, IL | El Paso, TX * | 1197 (1494) | IL MO KS OK TX NM TX | IL-1 I-57 IL-50 US 45 I-57 US 45 IL-54 US 36 IL-106 MO-73 MO-32 | Since 1926; W exten 1934; E exten 1942; E trunc 1972 |
| (US 154) | (Mullinville, KS) | (Dodge City, KS) | (36) | (KS) | US 400 KS-154 | Exist 1926-1982 |
| US 56 | (Independence, MO) Kansas City, MO | Springer, NM | 640 (661) | MO KS OK NM | US 24 US 40 US 71 The Paseo | Since 1957; Orig begin Kansas City, MO; W exten 1961; W trunc 1964 |
| (US 156) | (Ellsworth, KS +) | (Garden City, KS) | (101) | (KS) | KS-156 | Exist 1957-1982; Orig begin Larned, KS |
| US 58 | Virginia Beach, VA | Cumberland Gap, TN | 508 (535) | VA TN | Nill | Since 1932; Orig rte Virginia Beach, VA - Hillsville, VA; W exten Mouth of Wilson, VA 1934; Added sgmt fm Damascus, VA to Cumberland Gap, VA 1934; Sgmts joined 1935; Curr ext 1996 |
| US 158 | (Franklin, VA) Nags Head, NC | Mocksville, NC | 347 (359) | (VA) NC | US 258 | Since 1932; Orig begin Franklin, VA; E trunc Murfreeboro, NC 1940; E exten Wanchee, NC 1942; E trunc Nags Head, NC 1951 |
| US 258 | Ft. Monroe, VA | Jacksonville, NC | 217 (225) | VA NC | NC-58 | Since 1932; Orig begin Murfreesboro, NC; E exten 1940 |
U.S. Highways
| US 1 | US 11 | US 21 | US 31 | US 41 |
| US 51 | US 61 | US 71 | US 81 | US 91 |
| US 2[I] | US 10 [I] | US 20 [I] | US 30 | US 40 |
| US 50 | US 60 | US 70 | US 80 | US 90 |