US Highways Route - US41
| Route | From | To | Miles | States passed through | Replaced by | Notes |
| US 41 | Ft. Wilkins SP, MI | Miami, FL (Miami Beach, FL) | 2000 (2035) | MI WI IL IN KY TN GA FL | WI-32 WI-96 WI-47 US 45 WI-175 WI-57 WI-50 WI-31 IL-42A IL-131 IL-176 IL-43 IL-22 I-90 IL-50 Alt US 41 TN-12 US 41E Alt US 41 I-24 US 72 US 341 GA-11 US 441 FL-200 US 301 FL-776 US 1 FL-A1A | Since 1926; /W//E//W//E/ S exten Miami, FL 1950; Miami Beach 1955; S trunc? 2000 |
| US 141 | Covington, MI + | Bellvue, WI (Milwaukee, WI) | 176 (290) | MI WI MI WI | WI-29 R I-43 WI-42 WI-28 I-43 | Since 1926; N exten 1929; S trunc Grafton, WI 1977; Port Washington, WI 1979; Sheboygan, WI 1980; Curr 1981 |
| (US 241) [I] | |(Hopkinsville, KY) | (Nashville, TN) | (81) | (KY) (TN) | US 41E US 41 | Exist 1926-1929 |
| (US 241) [II] | (Murfreesboro, TN) | (Dothan, AL) | (378) | (TN) (AL) | US 231 US 431 AL-205 US 431 AL-21 CR-511 AL-9 US 280 US 431 | Exist 1930-1954 |
| US 341 | (Atlanta, GA) Barnesville, GA | Brunswick, GA | 226 (257) | GA | US 23 GA-42 US 41 US 129 GA-11 US 41 | Since 1926; N exten 1937; N trunc Perry, GA 1938; N exten 1949 |
| US 441 | Lake City, TN | Miami, FL | 936 (947) | TN NC GA FL | US 19 US 123 Alt US 441 FL-25 | Since 1926; Exten N High Springs, FL 1935; Baldwin, GA 1949; Curr 1952; S exten 1951 |
| (US 541) | (Chapman, FL) | (Bradenton, FL) | (46) | (FL) | Alt US 41 FL-685 (Bus US 41) FL-60 FL-45 US 41 | Exist 1932-1951; Orig begin Tampa, FL; N exten 1934 |
| US 641 | (Evansville, IN) Marion, KY | Holladay, TN + | 132 (149) | (IN) KY TN | US 41 US 60 | Since 1955; Orig S end Paris, TN; N trunc 1972; S exten 1977 |
| US 43 | (Hopkinsville, KY) Columbia, TN | Mobile, AL | 410 (523) | (KY) TN AL | US 41W Alt US 41 AL-5 | Since 1934; AASHO lists as beginning in Hopkinsville, KY 1934-1952; N trunc Green Hill, TN 1938; Curr N exten 1939 |
| (US 143) | (Glasgow, KY) | (Jackson, TN) | (226) | (KY) (TN) | US 31E US 70S TN-100 TN-20 US 412 | On maps 1934-1935; On maps 1944 + S exten from Nashville, TN to Jackson, TN |
| US 45 | Ontonagon, MI | Mobile, AL | 1297 (1299) | MI WI IL KY TN MS AL | WI-145 WI-100 I-57 US 45E TN-54 MS-373 MS-145 MS-39 | Since 1926; /W//E/ N exten 1934 |
| >US 47< | Nill | Nill | Nill | Nill | Nill | Not Assigned |
| US 49 | Piggott, AR | Gulfport, MS | 516 | AR MS | MS-3 US 49E [II] US 49E [I] US 51 US 80 MS-149 | Since 1926; /W//E//W//E/ N exten Clarksdale, MS 1928; Brinkley, AR 1963; Jonesboro, AR 1978; Curr 1980 |
U.S. Highways
| US 1 | US 11 | US 21 | US 31 | US 41 |
| US 51 | US 61 | US 71 | US 81 | US 91 |
| US 2[I] | US 10 [I] | US 20 [I] | US 30 | US 40 |
| US 50 | US 60 | US 70 | US 80 | US 90 |