US Highways Route - US1
| Route | From | To | Miles | States passed through | Replaced by | Notes |
| US 1 | Fort Kent, ME * | Key West, FL | 2377 (2390) | CT DC FL MA ME NY NJ NH PA RI MD VA NC SC GA | Alt US 1 RI-1A NY-1A NJ-27 PA-611 US 13 PA-10 I-85 Alt US 1 US 13 FL-13 FL-100 FL-5A | Since 1926; Exten S 1939 |
| US 201 | Sandy Bay Twp., ME * | Brunswick, ME | 157 (173) | ME | Alt US 201 | Since 1926 |
| (US 301) [I] | (Fredericksburg, VA) | (Lee Hall, VA) | (120) | (VA) | US 17 | 1925 plan; On some early maps 1926-1927 |
| US 301 [II] | (Farnhurst, DE) Glasgow, DE | Sarasota, FL | 1099 (1111) | DE MD VA NC SC GA FL | US 13 DE-71 DE-299 MD-648 MD-3 | Since 1932; /N//S//N/ Orig Rte Petersburg, VA - Lumberton, NC; N exten Baltimore, MD 1941; Farnhurst, DE 1960; S exten Pee Dee, SC 1933; Summerton, SC 1934; Tampa, FL 1949; Curr 1953; N end might be at Glasgow, DE |
| (US 401) [I] | (South Hill, VA) | (South Boston, VA) | (53) | (VA) | VA-12 VA-201 US 58 | Exist 1926-1931; W exten 1931 |
| (US 401) [II] | (Raleigh, NC) | (Walterboro, SC) | (272) | (NC) (SC) | Alt US 15 US 401 [III] US 15 Alt US 15 US 15 | Exist 1932-1934 |
| US 401 [III] | Paschall, NC + | Sumter, SC | 257 | NC SC | US 15 | Since 1957; Orig N end Norlina, NC; N exten 2001 |
| US 501 | Buena Vista, VA | Myrtle Beach, SC | 355 (363) | VA NC SC | US 360 VA-360 NC-5 SC-544 US 17 | Since 1926; N trunc Halifax, VA 1934; N exten 1934; S exten Conway, SC 1933; Curr 1935 |
| US 601 | Mt. Airy, NC | Tarboro, SC + (Hardeeville, SC) | 319 (339) | NC SC | US 52 US 321 | Since 1926; N trunc Halifax, VA 1933; N exten 1933; S trunc Salisbury, NC 1934; S exten Hardeeville, SC 1951; S trunc 1996; N trunc 1999; Orig rte completely replaced |
| US 701 | Four Oaks, NC + | Georgetown, SC (Charleston, SC) | 172 (233) | NC SC | SC-410 US 17 | Since 1933; S trunc 1992 |
| US 3 | Connecticut SF, NH * | Boston, MA | 273 (278) | NH MA | NH-3A MA-3A | Since 1926; N exten Pittsburg, NH 1937; Colebrooke, NH 1939; Curr 1940 |
| US 5 | Derby Line, VT * | New Haven, CT | 300 (313) | VT (NH) VT MA CT | NH-12 US 20 I-91 US 6/44 I-84 | Since 1926; In NH 1927-1929; Frmly cntd to Quebec City, PQ, Canada via PQ-5 |
| US 7 | Highgate Springs, VT * | Norwalk, CT (New York, NY) | 309 (313) | VT MA CT (NY) | MA-7A CT-41 NY-22 | Since 1926; In NY 1927-1929; Frmly cntd to Montreal, PQ, Canada via PQ-7 |
| US 9 [I] | (Rouses Point, NY *) Champlain, NY * | North Cape May, NJ ~ (Cape May, NJ) | 493 | NY NJ | US 11 NY-9B US 9W NY-9A NY-440 NJ-440 NJ-35 NJ-33 CR-547 NJ-157 | Since 1926; /E//W//W/ S exten Cape May, NJ 1932; Ferry; Frmly cntd to Monteal, PQ, Canada via PQ-9 |
| US 9 [II] | Lewes, DE ~ | Laurel, DE | 29 | DE | Nill | Since 1976 |
| (US 109) | (Hudson Falls, NY) | (New York, NY) | (214) | (NY) | US 9E US 4 US 9 | 1925 plan; On some early maps; unlikely NY posted the route |
| US 209 | Kingston, NY | Millersburg, PA (Clarks Ferry, PA) | 217 (231) | NY PA | US 15 PA-147 | Since 1926; N exten 1935; S trunc 1936 |
| (US 309) | (Waverly, NY) | (Philadelphia, PA) | (214) | (NY) (PA) | US 220 US 6 PA-309 PA-93 US 209 PA-248 PA-873 PA-309 PA-145 PA-309 | Exist 1926-1967; N exten 1930; S trunc Oak Lane, PA 1952; N trunc Tunkhannock, PA 1963 |
U.S. Highways
| US 1 | US 11 | US 21 | US 31 | US 41 |
| US 51 | US 61 | US 71 | US 81 | US 91 |
| US 2[I] | US 10 [I] | US 20 [I] | US 30 | US 40 |
| US 50 | US 60 | US 70 | US 80 | US 90 |